The organization I work for has implemented two factor authentication, with participants using the RSA SecureID app on mobile phones. Such authentication is required for having apps connect to the organization's Exchange service. For me, this has worked on my iPhone and iPad for connecting the native iOS apps for Mail, Calendar, Tasks, etc.
However, on my MacBookPro laptop running macOS High Sierra, attempts to connect the native Mail and Calendar apps to the Exchange service fail. The auto-discover dialogue seems to "thing about it", but then returns a message that it is unable to verify the account name or password, and never triggers the RSA SecureID authentication dialogue box. And similar results when attempting to manually configure the Mail connection.
The Office 2016 Outlook application on my MacBookPro can make the Exchange connection with the typical authentication preamble.
However, I enjoyed pulling the Exchange info into the native Calendar app so I could view it integrated with my personal activities.